Complete Testing & Optimization Guide
Optimal ranges, provider comparison, and strategies to improve your HDL Subfractions (Large/Small) levels
Only 1 providers include this test
Additional Specialized Tests
Large HDL-2 preferred for cardioprotection
Abnormal HDL Subfractions (Large/Small) levels can indicate underlying health issues that may go undetected without proper testing. Regular monitoring helps catch problems early when they're most treatable.
Understanding your HDL Subfractions (Large/Small) levels enables targeted interventions, tracks treatment effectiveness, and helps optimize your overall health and performance.
Breakdown of HDL particle types
Large HDL-2 more cardioprotective than small HDL-3. HDL subfraction analysis provides refined cardiovascular risk assessment.
Large HDL-2 preferred for cardioprotection
| Provider | Includes Test | Annual Cost | Total Biomarkers |
|---|---|---|---|
 Superpower | — | $199 | 100+ |
 WHOOP Advanced Labs | — | $349 | 65 |
 Labcorp OnDemand | — | $398 | 30+ |
| — | $486 | 40+ | |
| — | $468 | 83 | |
| — | $798 | 100+ | |
 InsideTracker | — | $680 | 48 |
 Function Health | ✓ | $499 | 100+ |
| — | $900 | 70+ | |
| — | $1150 | 110 | |
| — | $Varies | 75+ |
Choose from 1 providers that include this biomarker in their panels
HDL Subfractions (Large/Small) is a additional specialized tests biomarker that Breakdown of HDL particle types The normal reference range is Large HDL-2 preferred for cardioprotection. Regular testing helps track changes and identify potential health issues early.
1 out of 10 major blood testing providers include HDL Subfractions (Large/Small) in their standard panels. These include Function.
For most people, testing HDL Subfractions (Large/Small) 2-4 times per year is recommended to establish baseline levels and track trends. If you have abnormal results or are actively working to optimize this biomarker, more frequent testing (quarterly) may be beneficial. Always consult with your healthcare provider for personalized testing frequency recommendations.
The standard laboratory reference range for HDL Subfractions (Large/Small) is Large HDL-2 preferred for cardioprotection. However, many functional medicine practitioners recommend tighter "optimal" ranges for peak health and performance. Your ideal range may vary based on your age, sex, health goals, and other individual factors. Work with a healthcare provider familiar with optimal ranges to determine your target levels.
Most direct-to-consumer blood testing services that include HDL Subfractions (Large/Small) provide the physician order as part of their service. However, some states have restrictions on direct-to-consumer testing. Check with your chosen provider about availability in your state and whether they provide the necessary physician authorization.
Large HDL-2 more cardioprotective than small HDL-3. HDL subfraction analysis provides refined cardiovascular risk assessment.
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs and before making decisions about blood testing.
