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Optimal Biomarker Ranges

Learn what optimal blood test ranges really mean from leading functional medicine doctors and longevity researchers. This collection features 26 expert articles covering optimal ranges for metabolic health, hormones, inflammation, and more.

🎯 Why Optimal vs Normal?

Standard lab ranges detect disease. Optimal ranges prevent it. Learn the difference.

📚 Evidence-Based

All ranges from peer-reviewed research and clinical experience of leading practitioners.

Expert Articles

Peter Attia's Recommended Blood Tests

Nucleus HealthNucleus

Comprehensive guide to Peter Attia's blood test recommendations including his optimal ranges for longevity

🎯 Key Optimal Ranges:

ApoB:30-40 mg/dL (ceiling 60 mg/dL), HbA1c:<5.5%

Biomarkers:

ApoBLp(a)LDL-POGTTInsulinHbA1c

Blood Tests to Ask Your Doctor For

Dr. Mark HymanDr. Hyman Blog

Essential blood tests and optimal ranges from a functional medicine perspective

🎯 Key Optimal Ranges:

Fasting Glucose:<85 mg/dL, Fasting Insulin:2-5 mIU/dL, HbA1c:<5.5%

Biomarkers:

Fasting GlucoseFasting InsulinHbA1cLipids

The Functional Medicine Approach to High Cholesterol

Chris KresserRevolution Health Radio

Functional medicine approach to cholesterol including LDL particle number and inflammation markers

🎯 Key Optimal Ranges:

Total Cholesterol/HDL Ratio:<3.5, HDL:>60 mg/dL

Biomarkers:

LDL-CLDL-PApoBHDLTriglyceridesCRP

Which Lab Tests are Essential?

Chris KresserRevolution Health Radio

Chris Kresser discusses essential lab tests and what they reveal about root causes of health problems

🎯 Key Optimal Ranges:

HbA1c:4.6-5.3%, Uric Acid:<7-8 mg/dL

Biomarkers:

Fasting GlucoseFasting InsulinTSHFree T3Free T4LipidsCRP

Cortisol Decoded:The Myths &Truths

Ben GreenfieldBen Greenfield Life

Deep dive into cortisol physiology and optimal ranges for health and longevity

🎯 Key Optimal Ranges:

Morning Cortisol:14-18 μg/dL, DHEA:supports testosterone production

Biomarkers:

CortisolDHEATestosteroneProgesterone

High Cortisol Mysteries Unveiled &Advanced Lab Testing

Ben GreenfieldBen Greenfield Life

Advanced discussion of cortisol testing and comprehensive hormone panels

🎯 Key Optimal Ranges:

Custom ranges based on individual baselines and symptoms

Biomarkers:

CortisolDHEAACTHHormone Metabolites

Maximize Health with Vitamin D3

Dr. Rhonda PatrickNL Physio

Expert advice on vitamin D3 supplementation and optimal blood levels

🎯 Key Optimal Ranges:

Vitamin D:40-60 ng/mL

Biomarkers:

Vitamin D25-hydroxyvitamin D

How Vitamin D, Omega-3s &Exercise May Increase Longevity

Dr. Rhonda PatrickFoundMyFitness

Discussion of vitamin D deficiency risks and omega-3 benefits for longevity

🎯 Key Optimal Ranges:

Omega-3 Index:>8%, Vitamin D:40-60 ng/mL

Biomarkers:

Vitamin DOmega-3 IndexEPADHA

Homocysteine:Highs, Lows, and Optimals

Optimal DXOptimal DX Blog

Comprehensive guide to homocysteine optimal ranges for cardiovascular health

🎯 Key Optimal Ranges:

Homocysteine:<7 μmol/L (optimal), <10.5 μmol/L (acceptable)

Biomarkers:

Homocysteine

Biomarkers of Inflammation:High-Sensitivity CRP

Optimal DXOptimal DX Blog

Understanding hs-CRP as a marker of inflammation and cardiovascular risk

🎯 Key Optimal Ranges:

hs-CRP:<0.5 mg/L (optimal), <1 mg/L (low risk)

Biomarkers:

hs-CRP

Optimal GGT Levels:More Than a Liver Enzyme

Optimal DXOptimal DX Blog

GGT as a metabolic marker beyond liver health including insulin resistance risk

🎯 Key Optimal Ranges:

GGT:<18 U/L (men), <9 U/L (women), AST:<35 U/L, ALT:<33 U/L (men), <25 U/L (women)

Biomarkers:

GGTALTAST

A Functional Medicine Approach to Thyroid Hormone Labs

Rupa HealthRupa Health Blog

Comprehensive guide to thyroid testing from functional medicine perspective

🎯 Key Optimal Ranges:

TSH:0.5-2.5 mIU/L (optimal vs 0.45-4.12 standard)

Biomarkers:

TSHFree T3Free T4Reverse T3TPO Antibodies

Optimal Thyroid Levels for Males and Females

HealthlineHealthline

Evidence-based guide to optimal thyroid levels for longevity and health

🎯 Key Optimal Ranges:

TSH:0.5-2.5 mIU/L, 60-80th percentile associated with lowest mortality

Biomarkers:

TSHFree T3Free T4

Testosterone:Normal vs Optimal

Center for Hormones &WellnessHormone Wellness

Understanding the difference between normal and optimal testosterone levels

🎯 Key Optimal Ranges:

Men:>600 ng/dL for lower mortality risk, Women:10-55 ng/dL (premenopausal)

Biomarkers:

Total TestosteroneFree Testosterone

Interpreting Liver Enzyme Tests:ALT, AST, and ALP

Rupa HealthRupa Health Blog

Comprehensive guide to understanding and interpreting liver enzyme tests

🎯 Key Optimal Ranges:

ALT:19-25 U/L (women), 29-33 U/L (men), AST:<35 U/L

Biomarkers:

ALTASTALPGGT

The Biomarkers in 'Outlive'by Peter Attia

Nia HealthNia Health Blog

Summary of key biomarkers Peter Attia tracks in his book Outlive

🎯 Key Optimal Ranges:

ApoB:<60 mg/dL, VO2 Max:maximize for age, HbA1c:<5.5%

Biomarkers:

ApoBLp(a)LDL-PVO2 MaxHbA1cInsulin

Bryan Johnson's Blueprint:Longevity Bloodwork

I Won't DieI Won't Die Blog

Inside look at Bryan Johnson's comprehensive bloodwork and optimal ranges

🎯 Key Optimal Ranges:

Top 1% results across multiple biomarkers, Biological age:0.64 speed of aging

Biomarkers:

HbA1cCystatin CTestosteroneEstradiolCRPLipidsIGF-1

The Best Blood Tests for Longevity

My Vital MetricsMy Vital Metrics Blog

Comprehensive guide to blood tests that predict longevity and healthspan

🎯 Key Optimal Ranges:

Multi-marker approach for comprehensive longevity assessment

Biomarkers:

ApoBhs-CRPHomocysteineHbA1cVitamin DOmega-3 Index

Functional Medicine and Diabetes:Treat the Root Cause

Chris KresserChris Kresser Blog

Root cause approach to diabetes with focus on insulin and glucose regulation

🎯 Key Optimal Ranges:

Emphasis on early intervention before diabetes develops

Biomarkers:

Fasting InsulinFasting GlucoseHbA1cFructosamineTriglycerides

Best Blood Tests For Measuring Inflammation

Dr. HagmeyerDr. Hagmeyer Blog

Comprehensive guide to inflammation markers and their optimal ranges

🎯 Key Optimal Ranges:

hs-CRP:<1 mg/L, Homocysteine:5-7.2 μmol/L, Ferritin:context-dependent

Biomarkers:

CRPESRHomocysteineFerritinFibrinogen

hs-CRP and Low-Grade Inflammation:A Hidden Health Risk

DNA CareDNA Care Blog

Understanding hs-CRP as early marker of inflammation and cardiovascular disease

🎯 Key Optimal Ranges:

hs-CRP:<0.55 mg/L (men), <1 mg/L (women)

Biomarkers:

hs-CRP

Are Diabetes and Insulin Resistance Reversible?

Dr. Mark HymanDr. Hyman Blog

Evidence-based approach to reversing diabetes through optimal metabolic markers

🎯 Key Optimal Ranges:

Fasting glucose:<80 mg/dL, Never above 110-120 mg/dL post-meal

Biomarkers:

Fasting GlucoseFasting InsulinPost-prandial Glucose &Insulin

Functional Blood Test Ranges

Optimal DXOptimal DX

Comprehensive database of functional medicine optimal ranges vs standard ranges

🎯 Key Optimal Ranges:

Tighter ranges than conventional labs for early dysfunction detection

Biomarkers:

Multiple biomarkers across all systems

The One Test Your Doctor Isn't Doing That Could Save Your Life

Dr. Mark HymanDr. Hyman Blog

Focus on insulin testing as critical missing marker in standard panels

🎯 Key Optimal Ranges:

Fasting insulin:<10 mIU/dL, optimal:2-5 mIU/dL

Biomarkers:

Fasting InsulinHOMA-IR

Increase Testosterone Levels Naturally

Ben GreenfieldBen Greenfield Life

Evidence-based strategies for optimizing testosterone through lifestyle

🎯 Key Optimal Ranges:

Natural optimization targeting >600 ng/dL for men

Biomarkers:

TestosteroneDHEAEstradiolSHBG

VO2 Max - One of Andrew Huberman's Favorite Biomarkers

Nia HealthNia Health Blog

Understanding VO2 max as a key longevity biomarker discussed by Huberman

🎯 Key Optimal Ranges:

Top quartile for age associated with 5x lower mortality risk

Biomarkers:

VO2 MaxLactate Threshold

Understanding Your Results

These articles provide context for interpreting your blood test results. Remember that optimal ranges may differ from standard lab ranges, and should be considered alongside your individual health goals and medical history.

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