Systemic Inflammation Index (SII)
The Systemic Inflammation Index is calculated from platelet, neutrophil, and lymphocyte counts on a standard CBC. It reflects combined inflammatory and thrombotic activity and has been linked with cardiovascular events, cancer prognosis, and overall mortality. SII offers more information than single cell counts and can be tracked over time to follow inflammation.
Optimal range: who says what
No institution or named practitioner we track states an optimal target for Systemic Inflammation Index (SII). How we verify ranges.
- No stated targetNo separate optimal establishedHigher values track worse outcomes in cancer and cardiovascular cohorts; no validated target exists
- Lab reference intervalNo established lab reference interval (calculated index)What a lab report flags against. A lab interval is not an optimal target.
2 providers include this
Additional Specialized Tests
Why Systemic Inflammation Index (SII) matters
Calculated from platelet, neutrophil, and lymphocyte counts. Elevated SII predicts cardiovascular events, cancer prognosis, and all-cause mortality. More comprehensive than single inflammatory markers.
Which Providers Test Systemic Inflammation Index (SII)?
Superpower is both the cheapest ($349/year) and the most comprehensive (100+ biomarkers) panel that includes Systemic Inflammation Index (SII).
2 panels that include it, cheapest first
| Provider | Annual Cost | Total Biomarkers | $/Biomarker |
|---|---|---|---|
 Superpower | $349 | 100+ | $3.49 |
| $349 | 75+ | $4.65 |
$/Biomarker is annual cost divided by the panel's advertised biomarker count, not the price of this one test. We track 23 blood test providers (32 plans); 21 of those plans are itemized marker by marker. Compare all of them.
19 itemized panels do not include Systemic Inflammation Index (SII)
WHOOP Advanced Labs · Labcorp OnDemand · Life Extension Elite · Everlywell · Mito Health · InsideTracker · Function Health · Marek Health Base · Marek Health Comprehensive · Marek Health Complete · Marek Health Executive · Blueprint · Empirical Health · Oura Health Panels · SiPhox Health · Healthspan · Vitality Blueprint Standard · Vitality Blueprint Elite · Ultrahuman Blood Vision Annual
11 providers not itemized in our matrix
We have not itemized these marker by marker (some sell tests one at a time), so this page cannot say whether they offer Systemic Inflammation Index (SII). Check with them directly.
Life Extension Standard · Quest Health · Ultrahuman Blood Vision · Lifeforce · Hundred Health · Personalabs · Walk-In Lab · HealthLabs · WHOOP Specialized Panels · Marek Health Essential · Vitality Blueprint Upload
Frequently Asked Questions
What is the optimal range for Systemic Inflammation Index (SII)?
No separate optimal established: Higher values track worse outcomes in cancer and cardiovascular cohorts; no validated target exists. No established lab reference interval (calculated index).
Which blood test providers include Systemic Inflammation Index (SII)?
2 of the 21 blood testing panels we itemize marker by marker include Systemic Inflammation Index (SII) in their panels. This biomarker has limited availability.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed Sep 23, 2026 · First published Sep 30, 2025