APOE Genotype
APOE genotype identifies the variants of the apolipoprotein E gene (E2, E3, E4) that influence lipid metabolism and brain function. Carrying one APOE4 allele raises Alzheimer disease risk about threefold, and two alleles raise it substantially more. APOE4 also affects LDL cholesterol and cardiovascular risk, and genotype is generally tested once because it does not change.
Optimal range: who says what
No institution or named practitioner we track states an optimal target for APOE Genotype. How we verify ranges.
- No stated targetNot an optimization targetA fixed genotype used for risk context, not a value to change
- Lab reference intervalE2/E3, E3/E3 preferred; E3/E4, E4/E4 higher riskWhat a lab report flags against. A lab interval is not an optimal target.
1 providers include this
Advanced / Specialty Markers
Why APOE Genotype matters
APOE4 variant increases Alzheimer's disease risk 3-12x. Also affects cholesterol metabolism and cardiovascular risk. Guides lifestyle and preventive interventions.
Which Providers Test APOE Genotype?
Of the panels we itemize, only Marek Health Executive ($1950/year, 130+ biomarkers) includes APOE Genotype.
1 panel that includes it, cheapest first
| Provider | Annual Cost | Total Biomarkers | $/Biomarker |
|---|---|---|---|
| $1950 | 130+ | $15.00 |
$/Biomarker is annual cost divided by the panel's advertised biomarker count, not the price of this one test. We track 23 blood test providers (32 plans); 21 of those plans are itemized marker by marker. Compare all of them.
20 itemized panels do not include APOE Genotype
Superpower · WHOOP Advanced Labs · Labcorp OnDemand · Life Extension Elite · Everlywell · Mito Health · InsideTracker · Function Health · Marek Health Base · Marek Health Comprehensive · Marek Health Complete · Blueprint · Empirical Health · Oura Health Panels · SiPhox Health · Hims Labs · Healthspan · Vitality Blueprint Standard · Vitality Blueprint Elite · Ultrahuman Blood Vision Annual
11 providers not itemized in our matrix
We have not itemized these marker by marker (some sell tests one at a time), so this page cannot say whether they offer APOE Genotype. Check with them directly.
Life Extension Standard · Quest Health · Ultrahuman Blood Vision · Lifeforce · Hundred Health · Personalabs · Walk-In Lab · HealthLabs · WHOOP Specialized Panels · Marek Health Essential · Vitality Blueprint Upload
Frequently Asked Questions
What is the optimal range for APOE Genotype?
Not an optimization target: A fixed genotype used for risk context, not a value to change. Lab reference interval: E2/E3, E3/E3 preferred; E3/E4, E4/E4 higher risk. That is what a lab report flags against, not an optimal target.
Which blood test providers include APOE Genotype?
1 of the 21 blood testing panels we itemize marker by marker include APOE Genotype in their panels. This biomarker has limited availability.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed Aug 26, 2026 · First published Nov 30, 2025