TPO Antibodies (Thyroid Peroxidase)
TPO antibodies target thyroid peroxidase, an enzyme in hormone synthesis, and are the most sensitive marker of autoimmune thyroid disease. They are present in most cases of Hashimoto's thyroiditis and in many with Graves disease. Elevated TPO antibodies also predict future progression to overt hypothyroidism in people with subclinical disease.
Optimal range: who says what
No institution or named practitioner we track states an optimal target for TPO Antibodies (Thyroid Peroxidase). How we verify ranges.
- No stated targetNo separate optimal establishedA titer above the lab cutoff marks thyroid autoimmunity
- Published reference interval<34 IU/mLRupa Health
- Lab reference interval<35 IU/mL, Negative: <9 IU/mLWhat a lab report flags against. A lab interval is not an optimal target.
9 of 21 itemized panels
Thyroid Function
Why TPO Antibodies (Thyroid Peroxidase) matters
Elevated in Hashimoto's thyroiditis and Graves' disease. Helps diagnose autoimmune thyroid disorders. Predicts progression to hypothyroidism.
Which Providers Test TPO Antibodies (Thyroid Peroxidase)?
Cheapest: Mito Health at $297/year. Most comprehensive: Function Health, 160+ biomarkers for $365/year.
9 panels that include it, cheapest first
| Provider | Annual Cost | Total Biomarkers | $/Biomarker |
|---|---|---|---|
| $297 | 100+ | $2.97 | |
 Superpower | $349 | 100+ | $3.49 |
| $349 | 75+ | $4.65 | |
 Function Health | $365 | 160+ | $2.28 |
| $495 | 80+ | $6.19 | |
| $499 | 100+ | $4.99 | |
| $895 | 100+ | $8.95 | |
| $996 | 59 | $16.88 | |
| $1950 | 130+ | $15.00 |
$/Biomarker is annual cost divided by the panel's advertised biomarker count, not the price of this one test. We track 23 blood test providers (32 plans); 21 of those plans are itemized marker by marker. Compare all of them.
12 itemized panels do not include TPO Antibodies (Thyroid Peroxidase)
WHOOP Advanced Labs · Labcorp OnDemand · Life Extension Elite · Everlywell · InsideTracker · Marek Health Base · Blueprint · Empirical Health · Oura Health Panels · Healthspan · Vitality Blueprint Standard · Vitality Blueprint Elite
11 providers not itemized in our matrix
We have not itemized these marker by marker (some sell tests one at a time), so this page cannot say whether they offer TPO Antibodies (Thyroid Peroxidase). Check with them directly.
Life Extension Standard · Quest Health · Ultrahuman Blood Vision · Lifeforce · Hundred Health · Personalabs · Walk-In Lab · HealthLabs · WHOOP Specialized Panels · Marek Health Essential · Vitality Blueprint Upload
Experts discussing TPO Antibodies (Thyroid Peroxidase)
Podcast episodes where clinicians and researchers cover this marker in depth. Curated by hand; an episode is listed only when the marker is a substantial topic, not a passing mention.
- Understanding the Gut-Thyroid Axis, Hypothyroidism, and Hashimoto's
- Is Your Thyroid the Hidden Root Cause of Your Health Issues?Disclosure: Hyman co-founded Function Health, which appears in our blood-test comparisons.
- The Hidden Epidemic of Low Thyroid FunctionDisclosure: Hyman co-founded Function Health, which appears in our blood-test comparisons.
Frequently Asked Questions
What is the optimal range for TPO Antibodies (Thyroid Peroxidase)?
No separate optimal established: A titer above the lab cutoff marks thyroid autoimmunity. Published reference intervals: <34 IU/mL (Rupa Health). Lab reference interval: <35 IU/mL, Negative: <9 IU/mL. That is what a lab report flags against, not an optimal target.
Which blood test providers include TPO Antibodies (Thyroid Peroxidase)?
9 of the 21 blood testing panels we itemize marker by marker include TPO Antibodies (Thyroid Peroxidase) in their panels. This biomarker is widely available across major providers.
Related: YouBoost rates lifestyle and supplement interventions by evidence.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed Sep 23, 2026 · First published Sep 30, 2025