ANA Screen (Antinuclear Antibodies)
The ANA screen detects antibodies directed against components of the cell nucleus and is a first-line test for systemic autoimmune disease. It is typically positive in lupus, scleroderma, Sjogren syndrome, and mixed connective tissue disease, but low-titer positives also occur in healthy older adults. A positive result usually prompts specific antibody testing to identify the underlying condition.
Optimal range: who says what
No institution or named practitioner we track states an optimal target for ANA Screen (Antinuclear Antibodies). How we verify ranges.
- General guidance, no named sourceNegativeScreening test; a positive result is a prompt for follow-up, not a value to optimize. Low titers occur in ~10-15% of healthy people
- Lab reference intervalNegative (titer <1:40)What a lab report flags against. A lab interval is not an optimal target.
5 providers include this
Autoimmune Markers
Why ANA Screen (Antinuclear Antibodies) matters
Screens for systemic autoimmune diseases like lupus and scleroderma. Positive result requires further testing to identify specific antibodies.
Which Providers Test ANA Screen (Antinuclear Antibodies)?
Cheapest: Superpower at $349/year. Most comprehensive: Function Health, 160+ biomarkers for $365/year.
5 panels that include it, cheapest first
| Provider | Annual Cost | Total Biomarkers | $/Biomarker |
|---|---|---|---|
 Superpower | $349 | 100+ | $3.49 |
 Function Health | $365 | 160+ | $2.28 |
| $365 | 100+ | $3.65 | |
| $499 | 100+ | $4.99 | |
| $1188 | 70+ | $16.97 |
$/Biomarker is annual cost divided by the panel's advertised biomarker count, not the price of this one test. We track 23 blood test providers (32 plans); 21 of those plans are itemized marker by marker. Compare all of them.
16 itemized panels do not include ANA Screen (Antinuclear Antibodies)
WHOOP Advanced Labs · Labcorp OnDemand · Life Extension Elite · Everlywell · Mito Health · InsideTracker · Marek Health Base · Marek Health Comprehensive · Marek Health Complete · Marek Health Executive · Empirical Health · Oura Health Panels · SiPhox Health · Hims Labs · Vitality Blueprint Standard · Vitality Blueprint Elite
11 providers not itemized in our matrix
We have not itemized these marker by marker (some sell tests one at a time), so this page cannot say whether they offer ANA Screen (Antinuclear Antibodies). Check with them directly.
Life Extension Standard · Quest Health · Ultrahuman Blood Vision · Lifeforce · Hundred Health · Personalabs · Walk-In Lab · HealthLabs · WHOOP Specialized Panels · Marek Health Essential · Vitality Blueprint Upload
Experts discussing ANA Screen (Antinuclear Antibodies)
Podcast episodes where clinicians and researchers cover this marker in depth. Curated by hand; an episode is listed only when the marker is a substantial topic, not a passing mention.
- Healing Autoimmune Disease Using A Functional Medicine ApproachDisclosure: Hyman co-founded Function Health, which appears in our blood-test comparisons.
- #399 - Wisely Ordering Autoantibodies (ACP IM 2023)
- #147 - Rheumatoid Arthritis for the Internist
Frequently Asked Questions
What is the optimal range for ANA Screen (Antinuclear Antibodies)?
No institution or named practitioner we track states an optimal target for ANA Screen (Antinuclear Antibodies). General guidance without a named source: Negative (Screening test; a positive result is a prompt for follow-up, not a value to optimize). Lab reference interval: Negative (titer <1:40). That is what a lab report flags against, not an optimal target.
Which blood test providers include ANA Screen (Antinuclear Antibodies)?
5 of the 21 blood testing panels we itemize marker by marker include ANA Screen (Antinuclear Antibodies) in their panels. This biomarker has limited availability.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed Aug 26, 2026 · First published Sep 30, 2025