PSA Free (Prostate Cancer)
Free PSA measures the portion of prostate-specific antigen not bound to plasma proteins and is used alongside total PSA to refine prostate cancer risk. A higher percentage of free PSA suggests benign prostate enlargement, while a lower percentage raises concern for cancer. It helps reduce unnecessary biopsies when total PSA is only modestly elevated.
Optimal range: who says what
Institutions, researchers and practitioners draw the line in different places. Each position is listed with who holds it and, where a document states it, a link. How we verify ranges.
- Institution or studyFree/total ratio >25%Higher free fraction favors benign explanations of an elevated PSAA 25% free-PSA cutoff detected 95% of cancers while avoiding 20% of unnecessary biopsies in men with total PSA 4-10 ng/mL
- Lab reference intervalFree/Total PSA ratio >25% suggests benign diseaseWhat a lab report flags against. A lab interval is not an optimal target.
3 providers include this
Cancer Screening Markers
Why PSA Free (Prostate Cancer) matters
Helps distinguish benign prostate enlargement from cancer. Higher percentage of free PSA suggests benign condition. Used with total PSA for better specificity.
Which Providers Test PSA Free (Prostate Cancer)?
Mito Health is both the cheapest ($297/year) and the most comprehensive (100+ biomarkers) panel that includes PSA Free (Prostate Cancer).
3 panels that include it, cheapest first
| Provider | Annual Cost | Total Biomarkers | $/Biomarker |
|---|---|---|---|
| $297 | 100+ | $2.97 | |
 Superpower | $349 | 100+ | $3.49 |
| $365 | 100+ | $3.65 |
$/Biomarker is annual cost divided by the panel's advertised biomarker count, not the price of this one test. We track 23 blood test providers (32 plans); 21 of those plans are itemized marker by marker. Compare all of them.
18 itemized panels do not include PSA Free (Prostate Cancer)
WHOOP Advanced Labs · Labcorp OnDemand · Life Extension Elite · Everlywell · InsideTracker · Function Health · Marek Health Base · Marek Health Comprehensive · Marek Health Complete · Marek Health Executive · Empirical Health · Oura Health Panels · SiPhox Health · Hims Labs · Healthspan · Vitality Blueprint Standard · Vitality Blueprint Elite · Ultrahuman Blood Vision Annual
11 providers not itemized in our matrix
We have not itemized these marker by marker (some sell tests one at a time), so this page cannot say whether they offer PSA Free (Prostate Cancer). Check with them directly.
Life Extension Standard · Quest Health · Ultrahuman Blood Vision · Lifeforce · Hundred Health · Personalabs · Walk-In Lab · HealthLabs · WHOOP Specialized Panels · Marek Health Essential · Vitality Blueprint Upload
Frequently Asked Questions
What is the optimal range for PSA Free (Prostate Cancer)?
Published position: Free/total ratio >25% (Higher free fraction favors benign explanations of an elevated PSA). Lab reference interval: Free/Total PSA ratio >25% suggests benign disease. That is what a lab report flags against, not an optimal target.
Which blood test providers include PSA Free (Prostate Cancer)?
3 of the 21 blood testing panels we itemize marker by marker include PSA Free (Prostate Cancer) in their panels. This biomarker has limited availability.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed Sep 3, 2026 · First published Sep 30, 2025