Anion Gap
The anion gap is calculated from sodium, chloride, and bicarbonate and estimates unmeasured anions in blood. A high anion gap suggests metabolic acidosis from conditions such as diabetic ketoacidosis, lactic acidosis, kidney failure, or toxic ingestions (methanol, ethylene glycol, salicylates). A low gap can reflect hypoalbuminemia or lab error.
Optimal range: who says what
No institution or named practitioner we track states an optimal target for Anion Gap. How we verify ranges.
- General guidance, no named sourceWithin referenceNo separate optimal established
- Lab reference interval8-12 mEq/LWhat a lab report flags against. A lab interval is not an optimal target.
2 providers include this
Electrolytes & Minerals
Why Anion Gap matters
High anion gap indicates metabolic acidosis from conditions like diabetic ketoacidosis, lactic acidosis, or kidney failure. Low gap may indicate hypoalbuminemia.
Which Providers Test Anion Gap?
Cheapest: Labcorp OnDemand at $338/year. Most comprehensive: Superpower, 100+ biomarkers for $349/year.
2 panels that include it, cheapest first
| Provider | Annual Cost | Total Biomarkers | $/Biomarker |
|---|---|---|---|
 Labcorp OnDemand | $338 | 50+ | $6.76 |
 Superpower | $349 | 100+ | $3.49 |
$/Biomarker is annual cost divided by the panel's advertised biomarker count, not the price of this one test. We track 23 blood test providers (32 plans); 21 of those plans are itemized marker by marker. Compare all of them.
19 itemized panels do not include Anion Gap
WHOOP Advanced Labs · Life Extension Elite · Everlywell · Mito Health · InsideTracker · Function Health · Marek Health Base · Marek Health Comprehensive · Marek Health Complete · Marek Health Executive · Blueprint · Empirical Health · Oura Health Panels · SiPhox Health · Hims Labs · Healthspan · Vitality Blueprint Standard · Vitality Blueprint Elite · Ultrahuman Blood Vision Annual
11 providers not itemized in our matrix
We have not itemized these marker by marker (some sell tests one at a time), so this page cannot say whether they offer Anion Gap. Check with them directly.
Life Extension Standard · Quest Health · Ultrahuman Blood Vision · Lifeforce · Hundred Health · Personalabs · Walk-In Lab · HealthLabs · WHOOP Specialized Panels · Marek Health Essential · Vitality Blueprint Upload
Frequently Asked Questions
What is the optimal range for Anion Gap?
No institution or named practitioner we track states an optimal target for Anion Gap. General guidance without a named source: Within reference (No separate optimal established). Lab reference interval: 8-12 mEq/L. That is what a lab report flags against, not an optimal target.
Which blood test providers include Anion Gap?
2 of the 21 blood testing panels we itemize marker by marker include Anion Gap in their panels. This biomarker has limited availability.
Related: YouBoost rates lifestyle and supplement interventions by evidence.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed Aug 26, 2026 · First published Nov 30, 2025